Synthesis and quantitative structure–activity relationship study of substituted imidazophosphor ester based tetrazolo[1,5-b]pyridazines as antinociceptive/anti-inflammatory agents

• Wafaa M. Abdou,
• Neven A. Ganoub and
• Eman Sabry

Beilstein J. Org. Chem. 2013, 9, 1730–1736, doi:10.3762/bjoc.9.199

• , showed a notable antinociceptive and anti-inflammatory activity without toxic side-effects. Keywords: antinociceptive/anti-inflammatory agents; imidazophosphor esters; phosphonyl carbanions; ring closure; tetrazolo[1,5-b]pyridazine; Introduction Inflammation is a characteristic feature of disease